Osseointegration is a biologic concept. It refers to the formation of a direct interface between an implant and bone, without intervening soft tissue,i.e. the incorporation within living bone of an inanimate component. This is in essence an anchorage mechanism - nothing more, nothing less. such reliable anchorage allows the attachment of prosthetic to the bone by means of using fixtures (dental implants).
This phenomenon was first observed in the early 20th century, and dental surgeons realized the implications of osseointegration very quickly. Only certain materials can undergo osseointegration, with titanium being one of the most popular choices for procedures in which osseointegration is the goal. With other materials, the tissue will fail to grow into and around the implant, and it will not anchor.